This medication might consist of sugar and/or alcohol. Warning is suggested When you've got diabetes, alcohol dependence, or liver disease. Question your medical professional or pharmacist about employing this product or service properly.
Just before taking this medication, convey to your doctor or pharmacist In case you are allergic to promethazine or to dextromethorphan; or to almost every other phenothiazines (like prochlorperazine); or In case you have any other allergies.
If you are prescribed this medication on a regular agenda and pass up a dose, get it the moment you bear in mind. If it is near the time of the subsequent dose, skip the skipped dose. Acquire your subsequent dose on the frequent time. Will not double the dose to catch up.
That will help stop withdrawal, your health practitioner may lessen your dose slowly. Withdrawal is much more most likely In case you have utilised this medication for some time (quite a lot of months) or in significant doses. Notify your doctor or pharmacist right away In case you have withdrawal.
Promethazine HCl and Codeine Phosphate Oral Remedy is indicated for the temporary aid of coughs and higher respiratory indications affiliated with allergy or even the widespread cold in individuals 18 decades of age and older.
This medication may perhaps interfere with specific lab exams (for example some pregnancy checks, blood sugar tests, amylase/lipase degrees), perhaps creating Phony examination results. Be sure lab staff and all your Medical doctors know you use this drug.
In animal copy studies, codeine administered by the oral path to Expecting rats throughout the duration of organogenesis greater resorptions and lowered fetal weights at a dose around 25 times the most recommended human dose (MRHD) during the presence of maternal toxicity (see Info).
Will not flush medicines down the bathroom or pour them into a drain Except if instructed to take action. Correctly discard this merchandise when it's expired or no more essential. Speak to your pharmacist or neighborhood squander disposal company.
Promethazine might reduced seizure threshold. It ought to be used with warning in individuals with seizure Diseases or in folks who will be using concomitant remedies, for instance narcotics or regional anesthetics, which can also impact seizure threshold.
The approximated track record chance of main start defects and miscarriage for the indicated population is not known. All pregnancies Use a history risk of delivery defect, loss, or other adverse outcomes.
Critical, daily life-threatening, or lethal respiratory depression has become described with using opioids, which include codeine, one of the Lively components in Promethazine HCl and Codeine Phosphate Oral Resolution. Codeine makes dose-relevant respiratory depression by immediately acting within the Mind stem respiratory Centre that controls respiratory rhythm and should create irregular and periodic respiratory. Codeine is issue to variability in metabolism based mostly upon CYP2D6 genotype, which can cause a heightened publicity on the Energetic metabolite morphine [see Warnings and Precautions (5.three)]. Promethazine exerts a depressant impact on the respiratory Middle that is impartial of and additive to that of other respiratory depressants, like codeine [see Warnings and Safety measures (five.
Don't flush remedies down the toilet or pour them into a drain unless instructed to do so. Thoroughly discard this products when it really is expired or no longer needed. Speak to your Promethazine codeine syrup pharmacist or local squander disposal enterprise.
Ahead of employing this medication, Females of childbearing age must talk to their physician(s) about the dangers and Positive aspects. Tell your medical professional For anyone who is Expecting or Believe you may well be Expecting. For the duration of pregnancy, this medication just isn't proposed. It may a little bit enhance the hazard of birth defects if used throughout the initially two months of pregnancy. Also, utilizing it for some time or in significant doses close to the predicted shipping and delivery date may harm the unborn toddler.
The influence of promethazine and/or codeine over the later growth and growth on the newborn is unknown.